According to police in Cali, the shootings in that city took place on Sunday in he neighborhoods of Mojica, Alfonso Bonilla and Portero Grande, all located in the troubled southeastern Aguablancas district.
Among the dead are a 36-year old women, a shopkeeper and a minor.
Police said that one of the alleged shooters has been arrested.
FACT SHEET: Cali Crime Statistics
Shootings in Cali
In Medellin, police reported that three people were shot in the impoverished north of the city.
According to local newspaper El Colombiano, the shooting took place near La Finquita, a clandestine disco.
The victims allegedly were approached by three hooded men who assassinated their victims. Authorities are assuming the multiple homicide is gang-related.
FACT SHEET: Medellin crime statistics