Once Caldas took a 0-1 lead through Henry Rojas after 40 minutes of the match with Tolima, in Ibagué.
But the home side dominated in the second half and got a deserved equaliser through Franco Arizala in the 59th minute. Wilder Medina made it 2-1 seven minutes later and a third was added by Arizala with nine minutes to go. Tolima also hit the post twice.
Tolima have five points from three games, one point more than previous leaders Once Caldas. La Equidad could move into shared first place with a win over Boyacá Chicó on Sunday.
Cúcuta almost lost their home game with Junior, as the Barranquilla outfit scored through Camilo Ceballos in the 76th minute. Roberto Gamarra saved the day though, earning the hosts a point eight minutes later.
Although Cúcuta remain in first place, Envigado have a chance of conquering the top spot when they face Deportivo Cali this Sunday.