Born the son of a former governor, mining minister and registrar, Duque was groomed for a career in politics since he was young.
After finishing his law study at the elite Sergio Arboleda university in Bogota, Duque obtained one masters in law at Georgetown and one masters in public policy at the American University.
When Pastrana was succeeded by Uribe in 2002, Duque left for Washington DC where he became the chief of the culture department of the Inter-American Development Bank after fellow-Colombian Luis Aberto Moreno was elected director.
In 2011, Duque began working closely with Uribe as the assistant of a UN panel investigating an Israeli attack on activists bringing supplies to the West Bank.
When Uribe took part in congressional elections with his newly-founded Democratic Center Party, Duque was immediately elected senator in 2014.
The politician almost immediately became one of the moderate voices in the “uribista” party that had attracted politicians ranging from moderate conservatives to far-right radicals.
In Congress, Duque was extremely vocal regarding economic issues, being one of the main critics of the National Development Plan of the second four-year period of President Santos.
Duque resigned from the senate in 2017 after been handpicked by Uribe to lead the party’s efforts to regain control over the country’s most important office.
In an attempt to gather the support of dissident Conservative Party politicians, Duque agreed to let Marta Lucia Ramirez be his running mate for a coalition of political forces that have opposed a peace deal with the FARC.