Falcao scored in the 88th minute, giving Colombia a 1-0 win over Ecuador in a friendly on Friday at New Jersey’s Red Bull Arena.
The Porto striker entered in the 77th minute in place of Adrian Ramos.
The game drew a sellout crowd of 25,000 to the new home of the New York Red Bulls, which opened in March.
Both nations missed out on this year’s World Cup and are preparing for next summer’s Copa America.
Colombia plays the United States in a friendly on Tuesday.